. 2009 Jul 26;66(21):3435–3448. doi: 10.1007/s00018-009-0098-z

Table 2.

Thirty-six genes regulated by GRβ overexpression in HeLa cells are involved in 43 distinct biologic pathways in KEGG

No.	Gene symbol	Pathways in KEGG	No.	Gene symbol	Pathways in KEGG
1	ABCA3	hsa02010: ABC transporters—General	1	SDHC	hsa00020: Citrate cycle (TCA cycle)
2	ACY1	hsa00220: Urea cycle and metabolism of amino groups	2	NDUFA4	hsa00190: Oxidative phosphorylation
3	B2 M	hsa04612: Antigen processing and presentation,		NDUFA5
4	BCL2	hsa01510: Neurodegenerative Diseases		SDHC
		hsa04210: Apoptosis	3	ACY1	hsa00220: Urea cycle and metabolism of amino groups
		hsa04510: Focal adhesion	3	MAOA	hsa00220: Urea cycle and metabolism of amino groups
		hsa05030: Amyotrophic lateral sclerosis (ALS)	4	DUT	hsa00240: Pyrimidine metabolism
		hsa05060: Prion disease		TYMS
		hsa05210: Colorectal cancer		DTYMK
		hsa05215: Prostate cancer	5	GCLC	hsa00251: Glutamate metabolism
		hsa05222: Small cell lung cancer	6	MAOA	hsa00260: Glycine, serine and threonine metabolism
5	BRCA1	hsa04120: Ubiquitin mediated proteolysis	7	MAOA	hsa00340: Histidine metabolism
6	CANX	hsa04612: Antigen processing and presentation,	8	FAH	hsa00350: Tyrosine metabolism
7	CCNH	hsa04110: Cell cycle		MAOA
8	CD9	hsa04640: Hematopoietic cell lineage	9	MAOA	hsa00360: Phenylalanine metabolism
9	CDH2	hsa04514: Cell adhesion molecules (CAMs)	10	MAOA	hsa00380: Tryptophan metabolism
10	COL4A2	hsa01430: Cell Communication	11	GCLC	hsa00480: Glutathione metabolism
		hsa04510: Focal adhesion		HYAL2	hsa00531: Glycosaminoglycan degradation
		hsa04512: ECM-receptor interaction		FAH	hsa00643: Styrene degradation
		hsa05222: Small cell lung cancer		TYMS	hsa00670: One carbon pool by folate
11	CPE	hsa04940: Type I diabetes mellitus	12	HYAL2	hsa01032: Glycan structures—degradation
12	DTYMK	hsa00240: Pyrimidine metabolism,	13	COL4A2	hsa01430: Cell Communication
13	DUT	hsa00240: Pyrimidine metabolism		LAMB2
14	EFNB1	hsa04360: Axon guidance		TNC
15	EPHB2	hsa04360: Axon guidance	14	BCL2	hsa01510: Neurodegenerative Diseases
16	FAH	hsa00350: Tyrosine metabolism	15	ABCA3	hsa02010: ABC transporters—General
16	FAH	hsa00643: Styrene degradation	16	RPL32	hsa03010: Ribosome
17	GCLC	hsa00251: Glutamate metabolism	17	GTF2A2	hsa03022: Basal transcription factors
17	GCLC	hsa00480: Glutathione metabolism	18	POLB	hsa03030: DNA polymerase
18	GTF2A2	hsa03022: Basal transcription factors	19	RAP1B	hsa04010: MAPK signaling pathway
19	HYAL2	hsa00531: Glycosaminoglycan degradation	20	IL1RAP	hsa04060: Cytokine–cytokine receptor interaction
19	HYAL2	hsa01032: Glycan structures—degradation	21	CCNH	hsa04110: Cell cycle
20	IL1RAP	hsa04060: Cytokine–cytokine receptor interaction	22	BRCA1	hsa04120: Ubiquitin mediated proteolysis
20	IL1RAP	hsa04210: Apoptosis		UBE2D2
21	ITGA3	hsa04510: Focal adhesion	23	BCL2	hsa04210: Apoptosis
		hsa04512: ECM-receptor interaction		IL1RAP
		hsa04640: Hematopoietic cell lineage	24	MMP7	hsa04310: Wnt signaling pathway
		hsa04810: Regulation of actin cytoskeleton	25	EFNB1	hsa04360: Axon guidance
		hsa05222: Small cell lung cancer	25	EPHB2
22	ITGB1	hsa04360: Axon guidance		ITGB1
		hsa04510: Focal adhesion	26	BCL2	hsa04510: Focal adhesion
		hsa04512: ECM-receptor interaction		COL4A2
		hsa04514: Cell adhesion molecules (CAMs)		ITGA3
		hsa04670: Leukocyte transendothelial migration		ITGB1
		hsa04810: Regulation of actin cytoskeleton		LAMB2
		hsa05130: Pathogenic Escherichia coli infection—EHEC		PPP1R12A
		hsa05131: Pathogenic Escherichia coli infection—EPEC		RAP1B
		hsa05222: Small cell lung cancer		TNC
23	LAMB2	hsa01430: Cell Communication	27	COL4A2	hsa04512: ECM-receptor interaction
		hsa04510: Focal adhesion		ITGA3
		hsa04512: ECM-receptor interaction		ITGB1
		hsa05222: Small cell lung cancer		LAMB2
24	MAOA	hsa00220: Urea cycle and metabolism of amino groups		TNC
		hsa00260: Glycine, serine and threonine metabolism	28	CDH2	hsa04514: Cell adhesion molecules (CAMs)
		hsa00340: Histidine metabolism		ITGB1
		hsa00350: Tyrosine metabolism		PTPRM
		hsa00360: Phenylalanine metabolism	29	PTPRM	hsa04520: Adherens junction
		hsa00380: Tryptophan metabolism	30	B2M	hsa04612: Antigen processing and presentation,
25	MMP7	hsa04310: Wnt signaling pathway		CANX
26	NDUFA4	hsa00190: Oxidative phosphorylation	31	CD9	hsa04640: Hematopoietic cell lineage
27	NDUFA5	hsa00190: Oxidative phosphorylation		ITGA3
28	POLB	hsa03030: DNA polymerase	32	ITGB1	hsa04670: Leukocyte transendothelial migration
29	PPP1R12A	hsa04510: Focal adhesion		RAP1B
		hsa04720: Long-term potentiation	33	PPP1R12A	hsa04720: Long-term potentiation
		hsa04810: Regulation of actin cytoskeleton		RAP1B
30	PTPRM	hsa04514: Cell adhesion molecules (CAMs)	34	ITGA3	hsa04810: Regulation of actin cytoskeleton
30	PTPRM	hsa04520: Adherens junction		ITGB1
31	RAP1B	hsa04010: MAPK signaling pathway		PPP1R12A
		hsa04510: Focal adhesion	35	CPE	hsa04940: Type I diabetes mellitus
		hsa04670: Leukocyte transendothelial migration	36	BCL2	hsa05030: Amyotrophic lateral sclerosis (ALS)
		hsa04720: Long-term potentiation	37	BCL2	hsa05060: Prion disease
		hsa05211: Renal cell carcinoma	38	ITGB1	hsa05130: Pathogenic Escherichia coli infection—EHEC
32	RPL32	hsa03010: Ribosome	39	ITGB1	hsa05131: Pathogenic Escherichia coli infection—EPEC
33	SDHC	hsa00020: Citrate cycle (TCA cycle)	40	BCL2	hsa05210: Colorectal cancer
33	SDHC	hsa00190: Oxidative phosphorylation	41	RAP1B	hsa05211: Renal cell carcinoma
34	TNC	hsa01430: Cell Communication	42	BCL2	hsa05215: Prostate cancer
		hsa04510: Focal adhesion	43	BCL2	hsa05222: Small cell lung cancer
		hsa04512: ECM-receptor interaction		COL4A2
35	TYMS	hsa00240: Pyrimidine metabolism		ITGA3
35	TYMS	hsa00670: One carbon pool by folate		ITGB1
36	UBE2D2	hsa04120: Ubiquitin mediated proteolysis		LAMB2

Bold and Italic symbols, respectively, indicate the genes up-regulated and down-regulated by GRβ overexpression in both HeLa [10] and U-2 OS cells [11]

Data from Ref. [10]