Table 3.
Association of mtDNA D-loop MnlI site mutation with breast cancer risk
| RFLP pattern | Tumor Tissue, N (%) | Adjacent Non-tumor Tissue, N (%) | ||||
|---|---|---|---|---|---|---|
| Breast Cancer | BBD | OR (95% CI) | Breast Cancer | BBD | OR (95% CI) | |
| A | 201 (40.4) | 75 (37.7) | 1.00 (reference) | 48 (38.7) | 23 (36.5) | 1.00 (reference) |
| B | 102 (20.5) | 39 (19.6) | 0.91 (0.57–1.46) | 30 (24.2) | 10 (15.9) | 1.57 (0.63–3.89) |
| C | 61 (12.3) | 29 (14.6) | 0.71 (0.42–1.23) | 16 (12.9) | 7 (11.1) | 1.25 (0.42–3.72) |
| D | 43 (8.7) | 14 (7.0) | 1.07 (0.54–2.10) | 9 (7.3) | 6 (9.5) | 0.75 (0.23–2.51) |
| E | 35 (7.0) | 19 (9.6) | 0.73 (0.38–1.40) | 4 (3.2) | 8 (12.7) | 0.26 (0.07–1.02) |
| Atypical | 44 (8.9) | 12 (6.0) | 1.40 (0.67–2.92) | 14 (11.3) | 5 (7.9) | 1.68 (0.50–5.61) |
| Other | 11 (2.2) | 11 (2.5) | 0.37 (0.15–0.92) | 3 (2.4) | 4 (6.4) | 0.42 (0.09–2.08) |
| A | 201 (40.4) | 75 (37.7) | 1.00 (reference) | 48 (38.7) | 23 (36.5) | 1.00 (reference) |
| Any other RFLP patterns |
296 (59.6) | 124 (62.3) | 0.85 (0.60–1.21) | 76 (61.3) | 40 (63.5) | 1.01 (0.52–1.96) |