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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Pediatr Res. 2009 Dec;66(6):693–697. doi: 10.1203/PDR.0b013e3181bbce86

Table 6.

Surfactant protein gene allelic variants associated with risk for RDS.

Total number of infants in study SP-A SP-B Population Effect on RDS References
241 SP-A2 1A0/1A0 SP-B intron 4 polymorphism White population>28 weeks Increased risk 30
241 SP-A2 1A1/1 A1 SP-B intron 4 polymorphism White population>28 weeks Decreased risk 30
176 SP-A1 allele 6A2 Finnish population Increased risk 31
176 SP-A allele 6A3 Finnish population Decreased risk 31
684 SP-B Ile131 Thr Finnish population twins Determines the SP-A allele effect on RDS 32
White 511; Black 73 SP-A1 (6A2/6A2) SP-A2 (1A°/1A° or 1A°/* SP-B (9306 A/G or del/* White population Increased risk 33
White 511; Black 73 SP-A1 (6A3/6A3 or 6A3/*) SP-B (1580 T/T) Black population Reduced risk 33
White 511; Black n= 73 SP-B intron 4 del variant 33
White 511; Black 73 SP-B intron 4 ins variant Black females Increased risk 33
Parent-offspring trios 107 SP-A1-A2 haplotype 6A2-1A° Caucasian Finnish population Increased risk 34
Parent-offspring trios 107 SP-A1 6A3-1A1 6A4-1A5 Caucasian Finish population Decreased risk 34
198 SP-B intron 4 polymorphism Caucasian German population Increased risk 35
Singletons 441; Twins or multiples 480) SP-A1 6A2/6A2 SP-B exon 4 genotype Thr/Thr Caucasian Finnish population Increased risk 36
Singletons 441; Twins or multiples 480 SP-A 6A2 SP-B Ile/Thr Caucasian Finnish population Decreased risk 36
132 families SP-D/SP-A2 haplotype DA160-A/SP-A2 1A1 Also DA11-T present in SP-A containing haplotypes Mixed population Reduced risk 37