Table 1.

Multivariate analysis of polymorphic variants of the mitotic kinase genes with P_trend ≤ 0.05

Gene Name	rsID	Major Allele Homozygotes		Heterozygotes		Minor Allele Homozygotes		OR (95%CI) Per Allele	Ptrend	Q value
		Cases	Controls	Cases	Controls	Cases	Controls
BRD4	rs4808278	613	676	166	157	18	10	1.27 (1.02-1.58)	0.03	0.77
BUB1B	rs7182070	602	590	180	234	16	19	0.81 (0.66-1.00)	0.05	0.77
CDC42BPA	rs2802269	659	666	134	168	5	9	0.77 (0.61-0.98)	0.04	0.77
CDC42BPA	rs1929860	345	403	358	353	95	87	1.17 (1.00-1.36)	0.05	0.77
CIT	rs17496224	694	770	102	72	1	1	1.49 (1.08-2.05)	0.02	0.77
DBF4	rs9655955	706	718	89	119	3	6	0.73 (0.55-0.97)	0.03	0.77
EIF2AK4	rs2291627	646	715	143	124	9	4	1.34 (1.04-1.73)	0.02	0.77
FYN	rs6914091	221	297	412	414	165	131	1.33 (1.14-1.54)	0.0002	0.06
FYN	rs1465061	290	360	377	388	129	92	1.32 (1.13-1.53)	0.0003	0.06
FYN	rs12910	182	247	416	421	200	175	1.27 (1.10-1.46)	0.001	0.19
KIAA0999	rs10047459	544	612	227	208	27	23	1.22 (1.01-1.48)	0.04	0.77
KIAA0999	rs1473177	644	647	147	185	7	11	0.79 (0.63-0.99)	0.04	0.77
KIAA0999	rs17120241	625	614	156	213	17	15	0.81 (0.65-0.99)	0.04	0.77
PAK6	rs4924445	263	328	390	386	145	129	1.17 (1.01-1.35)	0.03	0.77
PAK6	rs7169803	471	451	284	335	43	57	0.84 (0.71-0.99)	0.04	0.77
PRKACB	rs12728744	734	750	63	89	1	3	0.70 (0.50-0.98)	0.04	0.77
ROCK1	rs17202375	638	714	153	124	7	5	1.43 (1.11-1.84)	0.005	0.53
RYK	rs10935104	568	639	204	190	26	14	1.29 (1.05-1.58)	0.01	0.77
RYK	rs9283588	595	661	182	174	21	8	1.30 (1.05-1.61)	0.02	0.77
RYK	rs1131262	595	661	182	173	21	9	1.28 (1.04-1.59)	0.02	0.77
STK4	rs17420378	420	393	313	362	64	86	0.85 (0.73-0.99)	0.04	0.77
STK4	rs6073636	420	394	313	364	64	85	0.85 (0.73-1.00)	0.05	0.77

NOTE: rsID: SNP identification number; OR: odds ratio; CI: confidence interval

Logistic regression analysis adjusted for age, geographical region, menopausal status, age at menarche, oral contraceptive use, age first birth, hormone replacement therapy and pack-years cigarette smoking