Table 2.

Association of SNPs in mitotic kinase genes with breast cancer by ER, PR and HER2 status of tumors

Gene Name	rsID	ER positive		PR positive		HER2 positive
		OR (95% CI) Per Allele	Ptrend	OR (95% CI) Per Allele	Ptrend	OR (95% CI) Per Allele	Ptrend
BRD4	rs4808278	1.25 (0.97-1.61)	0.09	0.98 (0.82-1.16)	0.82	1.40 (0.94-2.08)	0.10
BUB1B	rs7182070	0.74 (0.58-0.94)	0.01	0.72 (0.56-0.93)	0.01	0.72 (0.48-1.09)	0.13
BUB1B*	rs3759843	0.82 (0.67-1.00)	0.06	0.80 (0.65-1.00)	0.05	0.95 (0.68-1.33)	0.76
CDC42BPA	rs2802269	0.76 (0.57-1.01)	0.06	0.77 (0.57-1.03)	0.08	0.70 (0.43-1.14)	0.15
CDC42BPA	rs1929860	1.24 (1.04-1.47)	0.02	1.17 (0.98-1.40)	0.09	1.36 (1.02-1.82)	0.04
CIT	rs17496224	1.44 (0.99-2.08)	0.06	1.51 (1.03-2.20)	0.03	1.12 (0.59-2.15)	0.73
DBF4	rs9655955	0.73 (0.52-1.03)	0.07	0.75 (0.53-1.05)	0.10	0.89 (0.53-1.48)	0.65
EIF2AK4	rs2291627	127. (0.95-1.70)	0.11	1.38 (1.02-1.85)	0.03	1.14 (0.70-1.86)	0.60
EIF2AK4*	rs17720604	1.00 (0.76-1.31)	0.98	0.94 (0.70-1.24)	0.65	1.64 (1.12-2.40)	0.01
FYN	rs6914091	1.42 (1.20-1.68)	0.00006	1.45 (1.22-1.73)	0.00003	1.19 (0.90-1.58)	0.22
FYN	rs1465061	1.40 (1.18-1.67)	0.0001	1.40 (1.18-1.67)	0.0002	1.24 (0.92-1.66)	0.16
FYN	rs12910	1.38 (1.16-1.63)	0.0002	1.42 (1.19-1.69)	0.00008	1.19 (0.90-1.56)	0.23
KIAA0999	rs10047459	1.32 (1.06-1.64)	0.01	1.31 (1.04-1.64)	0.02	1.75 (1.24-2.46)	0.001
KIAA0999	rs1473177	0.75 (0.57-0.98)	0.04	0.76 (0.58-1.01)	0.06	0.66 (0.41-1.08)	0.10
KIAA0999	rs17120241	0.81 (0.63-1.03)	0.08	0.81 (0.62-1.04)	0.10	0.77 (0.50-1.17)	0.22
KIAA0999*	rs11216257	1.28 (1.03-1.58)	0.03	1.25 (1.00-1.56)	0.05	1.73 (1.23-2.42)	0.001
KIAA0999*	rs499910	1.14 (0.94-1.39)	0.19	1.12 (0.92-1.38)	0.26	1.40 (1.02-1.90)	0.03
KIAA0999*	rs2000615	1.17 (0.91-1.51)	0.23	1.15 (0.88-1.51)	0.30	1.54 (1.04-2.29)	0.03
PAK6	rs4924445	1.20 (1.02-1.43)	0.03	1.17 (0.98-1.39)	0.09	1.26 (0.96-1.65)	0.10
PAK6	rs7169803	0.86 (0.71-1.05)	0.14	0.88 (0.72-1.08)	0.22	0.94 (0.69-1.30)	0.72
PAK6*	rs2277562	1.13 (0.92-1.39)	0.26	1.13 (0.91-1.40)	0.26	1.56 (1.13-2.16)	0.007
PRKACB	rs12728744	0.77 (0.53-1.13)	0.19	0.68 (0.45-1.03)	0.07	1.14 (0.64-2.01)	0.66
PRKACB*	rs7546625	0.80 (0.64-1.00)	0.05	0.78 (0.62-0.99)	0.04	0.86 (0.59-1.25)	0.43
PRKACB*	rs1565823	1.20 (1.02-1.42)	0.01	1.21 (1.02-1.43)	0.03	0.98 (0.75-1.28)	0.87
PRKACB*	rs10782824	1.19 (1.01-1.40)	0.03	1.21 (1.02-1.43)	0.03	0.94 (0.72-1.24)	0.66
PRKACB*	rs1057738	1.20 (1.02-1.41)	0.03	1.21 (1.03-1.44)	0.02	0.95 (0.73-1.25)	0.73
PRKACB*	rs787858	1.19 (1.00-1.42)	0.05	1.17 (0.97-1.40)	0.10	1.06 (0.79-1.41)	0.72
PRKACB*	rs957828	0.97 (0.81-1.16)	0.74	0.97 (0.81-1.16)	0.72	0.72 (0.53-0.97)	0.03
ROCK1	rs17202375	1.52 (1.14-2.02)	0.004	1.61 (1.21-2.15)	0.001	1.15 (0.72-1.85)	0.55
RYK	rs10935104	1.35 (1.07-1.70)	0.01	1.33 (1.04-1.68)	0.02	1.43 (0.98-2.08)	0.06
RYK	rs9283588	1.35 (1.06-1.73)	0.02	1.34 (1.04-1.73)	0.02	1.45 (0.97-2.16)	0.07
RYK	rs1131262	1.33 (1.05-1.70)	0.02	1.33 (1.03-1.71)	0.03	1.48 (1.00-2.21)	0.05
RYK*	rs12186098	1.39 (0.96-2.01)	0.08	1.47 (1.01-2.15)	0.05	1.29 (0.71-2.35)	0.41
RYK*	rs13067800	1.39 (0.97-1.99)	0.07	1.42 (0.99-2.04)	0.06	1.96 (1.16-3.30)	0.01
STK4	rs17420378	0.83 (0.69-0.99)	0.04	0.87 (0.72-1.05)	0.33	0.90 (0.67-1.22)	0.50
STK4	rs6073636	0.83 (0.69-1.00)	0.05	0.87 (0.72-1.05)	0.16	0.90 (0.67-1.22)	0.50

NOTE: ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; OR, odds ratio; CI, confidence interval

Logistic regression analysis adjusted for age, geographical region, menopausal status, age at menarche, oral contraceptive use, age first birth, hormone replacement therapy and cigarette smoking in packyears

Only SNPs in genes listed in Table 1 are shown in Table 2

^*Non-significant association in the complete case-control study population