Table 3.
Gene Name | rsID | Major Allele Homozygotes |
Heterozygotes |
Minor Allele Homozygotes |
OR (95%CI) Per Allele |
Ptrend | |||
---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Cases | Controls | Cases | Controls | ||||
CIT | rs4766950* | 271 | 260 | 499 | 502 | 232 | 228 | 1.02 (0.90-1.16) | 0.79 |
FYN | rs6914091 | 317 | 337 | 488 | 480 | 167 | 170 | 1.03 (0.90-1.17) | 0.68 |
KIAA0999 | rs7928320* | 598 | 604 | 342 | 334 | 65 | 52 | 1.07 (0.92-1.24) | 0.38 |
PAK6 | rs16970458* | 497 | 492 | 400 | 423 | 102 | 80 | 1.04 (0.90-1.19) | 0.62 |
ROCK1 | rs17202375 | 805 | 807 | 180 | 181 | 8 | 12 | 0.96 (0.77-1.18) | 0.69 |
RYK | rs9283588 | 781 | 789 | 222 | 212 | 14 | 11 | 1.07 (0.89-1.30) | 0.46 |
NOTE: rsID: SNP identification number; OR: odds ratio; CI: confidence interval
Logistic regression analysis adjusted for age, geographical region, menopausal status, age at menarche, oral contraceptive use, age first birth, hormone replacement therapy and pack-years cigarette smoking
rs7928320 was significant in the general model in Mayo study (Ptrend = 0.0004)
rs4766950 and rs1697045 were significant in the general model in the pre-menopausal women