Table 4.

Association of specific haplotypes with breast cancer risk

Haplotypes and Blocks	Haplotype	Hap-Frequency	Hap-Score	P value
BRD4 block 1	21112	0.115	2.04	0.04
BUB1B block 1	1122	0.147	−2.04	0.04
DBF4 block 1	21122	0.068	−2.31	0.02
KIAA0999 block 1	11121	0.110	−2.10	0.04
MAST2 block 1	12112122	0.066	−2.08	0.04
MAP2K4 block 1	1211111	0.178	2.76	0.006
ROCK1 block 1	1122	0.091	2.70	0.007
RYK block 1	1221121	0.125	2.47	0.01
STK4 block 1	1122111122	0.139	−2.41	0.02

NOTE: 1=major allele, 2=minor allele; Hap-Frequency: frequency of each haplotype in the controls; Hap-Score: statistical measurement of association of each specific haplotype with breast cancer risk

BRD4 block 1: rs4808272 rs11880801 rs8104223 rs4809130 rs4808278

BUB1B block 1: rs1801376 rs1047130 rs2305653 rs7182070

DBF4 block 1: rs9655955 rs13238458 rs11764107 rs4728713 rs6977687

KIAA0999 block 1: rs687172 rs11216164 rs681524 rs1473177 rs499910

MAP2K4 block 1: rs8067785 rs7216812 rs12603036 rs17614045 rs2322123 rs9907196 rs10432016. The individual SNPs in this block displayed no significant associations with breast cancer risk (in bold and underlined). *The global P value for this block is also significant at 0.04

MAST2 block 1: rs4660891 rs12732188 rs4660318 rs12141934 rs10789481 rs12759880 rs2275426 rs1707336. The individual SNPs in this block displayed no significant associations with breast cancer risk (in bold and underlined)

ROCK1 block 1: rs7227454 rs288989 rs17202375 rs1481280

RYK block 1: rs13067800 rs9283588 rs10935104 rs6795658 rs9859680 rs1131262 rs4339087

STK4 block 1: rs17322289 rs2284271 rs6017460 rs17420378 rs6073604 rs10485454 rs6073627 rs6073629 rs8000 rs607363