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. Author manuscript; available in PMC: 2009 Dec 21.
Published in final edited form as: Neurobiol Aging. 2008 Mar 4;30(8):1238–1244. doi: 10.1016/j.neurobiolaging.2007.12.024

Fig. 1.

Fig. 1

Mean neuronal volumes (μm3) of APPswe/PS1dE9 (n = 7) and ntg (n = 5) littermates with B6/C3 background which were processed as frozen sections. The mean cortical neuronal volumes in the tg mice (mean = 1050 ± 53 μm3) compared to those of their ntg littermates (mean = 759 ± 63 μm3) were 38% larger (*p < 0.01) (A); this was largely due to the greater proportion of medium-sized cortical neurons in the tg mice compared to the ntg littermates. Statistical analysis (Kolmogorov–Smirnov Test) demonstrated highly significant differences (**p < 0.001) in the distribution of the cortical neuronal sizes between tg vs. ntg littermates (B). No significant differences in the neuron counts were noted in the cortex of the APPswe/PS1dE9 and ntg littermates (C).