Table 2. T2D susceptible alleles and genotype frequencies for the ERF participants.
Locus | Chr | SNPs | Position (bp) | Alleles | N | Allele Freq. (n) | Genotype Frequencies (n) | Phw | Freq. Ref. | |||
A1/A2 | A1 | A2 | A1A1 | A1A2 | A2A2 | |||||||
IGF2BP2 | 3 | rs4402960 | 186994389 | T/G | 2891 | 28.8 | 71.2 | 8.8 | 40.1 | 51.1 | 0.238 | 0.29–0.30 |
(833) | (2058) | (253) | (1159) | (1479) | ||||||||
CDKN2B | 9 | rs10811661 | 22124094 | T/C | 2888 | 86.6 | 13.4 | 75.1 | 23 | 1.9 | 0.748 | 0.83–0.85 |
(2501) | (387) | (2168) | 666 | 54 | ||||||||
CDKAL1 | 6 | rs7754840 | 20769229 | C/G | 2871 | 32.7 | 67.3 | 11.4 | 43.3 | 45.3 | 0.127 | 0.31–0.36 |
(993) | (2115) | (326) | (1229) | (1316) | ||||||||
PPARG | 3 | rs1801282 | 12368125 | C/G | 2955 | 90.1 | 9.9 | 81.3 | 17.7 | 1 | 0.757 | 0.82–0.86 |
(2662) | (293) | (2402) | (523) | (30) | ||||||||
SLC30A8 | 8 | rs13266634 | 118253964 | C/T | 2934 | 69.2 | 30.8 | 47.4 | 43.6 | 9 | 0.260 | 0.61–0.75 |
(2030) | (904) | (1391) | (1278) | (265) | ||||||||
HHEX | 10 | rs1111875 | 94452862 | C/T | 2940 | 59.2 | 40.8 | 34.9 | 48.4 | 16.7 | 0.939 | 0.52–0.64 |
(1740) | (1200) | (1028) | (1423) | (489) | ||||||||
KCNJ11 | 11 | rs5219 | 17366148 | T/C | 2935 | 33.6 | 66.4 | 11.4 | 44.4 | 44.2 | 0.804 | 0.46–0.47 |
(986) | (1949) | (335) | (1304) | (1296) | ||||||||
TCF7L2 | 10 | rs7903146 | 114748339 | T/C | 2916 | 28.5 | 71.5 | 7.8 | 41.3 | 50.9 | 0.467 | 0.18–0.26 |
(831) | (2084) | (228) | (1204) | (1482) | ||||||||
FTO | 16 | rs8050136 | 52373776 | A/C | 2942 | 43.1 | 56.9 | 17.2 | 51.8 | 31.0 | 0.011 | 0.38 |
(1268) | (1674) | (505) | (1524) | (913) |
Chr. = Chromosome, Risk allele for type 2 diabetes underlined. Phw = p value for hardy-weinberg. Freq. Ref. = reference frequency.