Table 3. Individual effects of T2D polymorphisms.
SNP Locus | Risk Alle. | Freq. | TRAIT | ||||||||||||||
BMI | FMI | FAT | WC | WHR | |||||||||||||
β | Se | p | β | se | p | β | se | p | β | se | p | β | se | p | |||
rs13266634 | C | 0.69 | −0.18 | 0.14 | 0.28 | −0.1 | 0.1 | 0.43 | −0.09 | 0.23 | 0.76 | −0.13 | 0.34 | 0.68 | −1.33E-03 | 2.07E-03 | 0.59 |
SLC30A8 | |||||||||||||||||
rs10811661 | T | 0.87 | −0.04 | 0.18 | 0.87 | −0.02 | 0.14 | 0.92 | −0.01 | 0.3 | 0.99 | 0.06 | 0.46 | 0.91 | 2.02E-03 | 2.78E-03 | 0.54 |
CDKN2AB | |||||||||||||||||
rs7754840 | C | 0.33 | 0.15 | 0.13 | 0.35 | 0.08 | 0.1 | 0.5 | 0.17 | 0.22 | 0.52 | 0.2 | 0.33 | 0.61 | −4.29E-04 | 2.00E-03 | 0.86 |
CDKAL1 | |||||||||||||||||
rs4402960 | T | 0.29 | 0.17 | 0.14 | 0.29 | 0.07 | 0.1 | 0.56 | −0.06 | 0.22 | 0.83 | 0.35 | 0.33 | 0.38 | 8.09E-04 | 2.05E-03 | 0.74 |
IGF2BP2 | |||||||||||||||||
rs1111875 | C | 0.59 | 0.11 | 0.13 | 0.47 | 0.06 | 0.09 | 0.58 | 0.16 | 0.21 | 0.53 | 0.14 | 0.31 | 0.71 | 6.92E-04 | 1.91E-03 | 0.76 |
HHEX | |||||||||||||||||
rs1801282 | C | 0.9 | 0.25 | 0.22 | 0.31 | 0.22 | 0.16 | 0.24 | 0.65 | 0.35 | 0.13 | 0.38 | 0.52 | 0.53 | −8.17E-05 | 3.17E-03 | 0.98 |
PPARG | |||||||||||||||||
rs5219 | T | 0.34 | −0.04 | 0.13 | 0.81 | 2.1E-03 | 0.1 | 0.99 | 0.13 | 0.22 | 0.64 | 0.16 | 0.33 | 0.68 | 1.67E-03 | 1.99E-03 | 0.48 |
KCNJ11 | |||||||||||||||||
rs7903146 | T | 0.28 | 0.1 | 0.14 | 0.56 | 0.08 | 0.1 | 0.5 | 0.28 | 0.23 | 0.33 | 0.39 | 0.34 | 0.34 | 2.32E-03 | 2.09E-03 | 0.35 |
TCF7L2 | |||||||||||||||||
rs8050136 | A | 0.43 | 0.45 | 0.13 | 3.0E-03* | 0.31 | 0.09 | 7.0E-03* | 0.51 | 0.21 | 5.3E-02 | 0.79 | 0.32 | 3.0E-02* | 1.02E-03 | 1.96E-03 | 0.66 |
FTO |
All analyses are adjusted for sex and age. BMI = body mass index, FMI = fat mass index, FAT = fat %, WC = waist circumference, WHR = waist to hip ratio. b = beta coefficient, se = standard error, p = p value, * = p<0.05.