Figure 3.

Open field test of wild-type and 5-HT_1AR⁻ males (A) and females (B). Fifteen wild-type and homozygotic males, 10 wild-type females, and 12 heterozygotic females were studied. The number of crosses into the center was normalized to locomotor activity and expressed as the percent of total crosses. Time spent in the center of the test apparatus is expressed as the percent of total time (10 min). Time per cross indicates the average time spent in the center of the open field for each entry. Asterisks designate statistically significant differences (P < 0.05) for the mutant as compared with the wild-type group.