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Model of Cis-Regulation at an Activated Promoter. Top Row: Organization of functional elements for a gene. Enh: enhancer; Sil: silencer; Ins: insulator; Pro: promoter. The p300-engaged enhancer will activate transcription, unless CTCF binds to an insulator site and blocks this activity. Middle row: Areas of distribution of H3 histone marks at an activated promoter. Bottom row: Nucleosome (circles) distribution at an activated promoter.
