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. Author manuscript; available in PMC: 2009 Dec 21.
Published in final edited form as: Bioorg Med Chem. 2008 Nov 1;16(24):10257–10269. doi: 10.1016/j.bmc.2008.10.046

Scheme 4. Reagents and conditions.

Scheme 4

(a) i. NMM, ClCO2Et, THF; ii. NaBH4, MeOH; (b) n-BuLi/hexane, THF; (c) i. 4 N HCl/Et2O; ii. CH3(CH2)13CHOHCOOH, WSCI, HOBt, Et3N, CH2Cl2; (d) Dess-Martin periodinane, CH2Cl2; (e) EtBr, Bu4NHSO4, 50% NaOH, C6H6.