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. Author manuscript; available in PMC: 2009 Dec 21.
Published in final edited form as: Bioorg Med Chem. 2008 Nov 1;16(24):10257–10269. doi: 10.1016/j.bmc.2008.10.046

Scheme 6. Reagents and conditions.

Scheme 6

(a) NaOCl, TEMPO, NaBr, NaHCO3, EtOAc/PhCH3/H2O 3:3:0.5, −5 °C; (b) Ph3P=CHCOOMe, THF, reflux; (c) H2, 10% Pd/C, MeOH; (d) 4 N HCl/Et2O, (e) Ph(CH2)6COOH, WSCI, HOBt, Et3N, CH2Cl2; (f) 1 N NaOH, dioxane.