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. Author manuscript; available in PMC: 2009 Dec 21.
Published in final edited form as: Bioorg Med Chem. 2008 Nov 1;16(24):10257–10269. doi: 10.1016/j.bmc.2008.10.046

Table 2.

Inhibition of PLA2 by 2-oxoamides based on esters of γ- and ε-amino acids and related compounds. Average percent inhibition and standard error (n=3) reported for each compound at 0.091 mole fraction. N.D. signifies compounds with less than 25% inhibition (or no detectable inhibition).

Entry Structure GIVA
cPLA2 		GVIA
iPLA2 		GV
sPLA2
12a graphic file with name nihms-164346-t0020.jpg 83 ± 4 65 ± 9 65 ± 9
12b graphic file with name nihms-164346-t0021.jpg 87 ± 13 78 ± 9 86 ± 6
12c graphic file with name nihms-164346-t0022.jpg 85 ± 5 72 ± 2 87 ± 4
17 graphic file with name nihms-164346-t0023.jpg 64 ± 4 74 ± 5 52 ± 7
18 graphic file with name nihms-164346-t0024.jpg 62 ± 12 66 ± 5 N.D.
19 graphic file with name nihms-164346-t0025.jpg 85 ± 4 N.D. N.D.
8l graphic file with name nihms-164346-t0026.jpg 87 ± 1 N.D. 78 ± 8
26 graphic file with name nihms-164346-t0027.jpg 32 ± 5 N.D. N.D.
27 graphic file with name nihms-164346-t0028.jpg 62 ± 14 51 ± 2 64 ± 12