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. Author manuscript; available in PMC: 2009 Dec 21.
Published in final edited form as: Bioorg Med Chem. 2008 Nov 1;16(24):10257–10269. doi: 10.1016/j.bmc.2008.10.046

Table 3.

Inhibition of PLA2 by 2-oxoamide and amide containing 7-phenylheptanoyl chain. Average percent inhibition and standard error (n=3) reported for each compound at 0.091 mole fraction. N.D. signifies compounds with less than 25% inhibition (or no detectable inhibition).

Entry Structure GIVA
cPLA2 		GVIA
iPLA2 		GV
sPLA2
37a graphic file with name nihms-164346-t0029.jpg 54 ± 4 31 ± 10 30 ± 2
37b graphic file with name nihms-164346-t0030.jpg 82 ± 9 81 ± 10 69 ± 9
32a graphic file with name nihms-164346-t0031.jpg N.D. N.D. N.D.
32b graphic file with name nihms-164346-t0032.jpg 36 ± 3 57 ± 12 66 ± 9
42 graphic file with name nihms-164346-t0033.jpg N.D. N.D. 95
XI(50)
0.003 ±
0.0004
43 graphic file with name nihms-164346-t0034.jpg N.D. N.D. N.D.