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. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: Ultrasound Med Biol. 2009 Oct 24;35(12):1982–1994. doi: 10.1016/j.ultrasmedbio.2009.07.001

(a) Thrombolysis rate as a function of peak negative pressure at the therapy focus (mean +/− standard deviation, n = 8). Pressures below 6 MPa had no observable effect on the clot after 5 minutes of treatment. At 6 MPa or greater, an increase in rate is observed, and the clot is quickly dissolved in times ranging between 80 - 300 seconds. (b) Percentage of time initiated vs. peak negative pressure. The percentage of time initiated is defined as the initiated time divided by the total treatment time. Initiation here refers to the initiation of a temporally changing backscatter described in the text. For pressures < 6MPa, initiation was never detected. Above 6 MPa, initiation was always observed and the initiated state remained throughout the treatment.

(a) Thrombolysis rate as a function of peak negative pressure at the therapy focus (mean +/− standard deviation, n = 8). Pressures below 6 MPa had no observable effect on the clot after 5 minutes of treatment. At 6 MPa or greater, an increase in rate is observed, and the clot is quickly dissolved in times ranging between 80 - 300 seconds. (b) Percentage of time initiated vs. peak negative pressure. The percentage of time initiated is defined as the initiated time divided by the total treatment time. Initiation here refers to the initiation of a temporally changing backscatter described in the text. For pressures < 6MPa, initiation was never detected. Above 6 MPa, initiation was always observed and the initiated state remained throughout the treatment.