Table 1.

PBN Effect on Choline Deficiency Induced Preneoplastic Lesions^*

		GST-P-positive lesions
Group	Treatment(s)	no./cm3	Size(mm3)	8-OHG (8-OHdG/106 dG)	Av. PBN exposure (mg/kg body wt/day)
1	CDAA	190 ± 10	1.92 ± 0.31	18.92 ± 1.96	0
2	CDAA + PBN (low)	170 ± 28	0.33 ± 0.20**	13.10 ± 2.56**	6.06 ± 1.07
3	CDAA + PBN (middle)	149 ± 15**	0.17 ± 0.06**	5.11 ± 1.24**	32.86 ± 4.81
4	CDAA + PBN (high)	142 ± 10**	0.10 ± 0.05**	2.55 ± 0.83**	61.76 ± 8.90
5	CSAA	0		1.00 ± 0.10	0
6	CSAA + PBN (high)	0		1.00 ± 0.17	64.45 ± 9.53

^*PBN was administered in the drinking water, data taken at 12 weeks; Summary of data taken from Table 1 and Table 2 of Nakae, D. et al;(131)

^**Significantly different from group p<0.01.