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. Author manuscript; available in PMC: 2009 Dec 21.
Published in final edited form as: Science. 2009 Dec 11;326(5959):1549–1554. doi: 10.1126/science.1181046

Figure 2. Regulation of ALS pathogenesis by miR-206.

Figure 2

(A) Age of disease onset for G93A-SOD1 (black) (n=9) (188 days), miR-206−/−; G93A-SOD1 (red) (n=10) (187 days), and miR-206 KO (blue) littermates. (B) Days of disease progression for G93A-SOD1 (78 days) and miR-206−/−; G93A-SOD1 littermates (56 days). p < 0.005 by log-rank test. (C) Survival curve for G93A-SOD1 (266 days), miR-206−/−;G93A-SOD1 (244 days). p < 0.05 by log-rank test. (D) Survival of G93A-SOD1 and miR-206−/−;G93A-SOD1 mice. *p < 0.02 by t test. (E) G93A-SOD1 and miR-206−/−;G93A-SOD1 mice at approximately 7.5 months of age. (F) X-ray reveals kyphosis in miR-206−/−;G93A-SOD1 mice. (G) Wheat-germ agglutinin (WGA) staining of transverse sections of muscle show accelerated muscle atrophy in miR-206−/−;G93A-SOD1 mice compared to G93A-SOD1 littermates. Scale bar= 100 µm. Values represent means ± SEM.