Table 2.
Evidence for linkage (P < 0.05) from the RA genome scan performed with 309 markers outside of the HLA region
| D number | AFM* | Position | Region | S | NS | P | pM |
|---|---|---|---|---|---|---|---|
| D1S228 | 196xb4 | 32.4 | 1.1/1p36-pter | 89.5 | 56.8 | 0.0035 | 0.0065 |
| D1S238 | 205xg1 | 206.7 | 1.2/1q31-32 | 94.2 | 68.5 | 0.022 | 0.099 |
| D2S380 | 321xd9 | 88.0 | 2.1/2p13-pter | 102.1 | 78.7 | 0.041 | 0.010 |
| D2S377 | 319zf9 | 228.2 | 2.2/2q33-37 | 84.9 | 61.0 | 0.024 | 0.013 |
| D2S2354 | a046we1 | 235.0 | 2.2 | 91.1 | 58.9 | 0.0043 | 0.0054 |
| D3S1267 | 116xh2 | 141.1 | 3.1/3q13 | 96.1 | 63.4 | 0.032 | 0.039 |
| D3S1262 | 059xa9 | 207.2 | 3.2/3q27 | 97.0 | 75.0 | 0.046 | 0.11 |
| D5S422 | 211yc7 | 163.9 | 5.1/5q32-33 | 99.5 | 75.2 | 0.033 | 0.045 |
| D6S292 | 203za9 | 138.2 | 6.1/6q21-23 | 89.0 | 66.7 | 0.036 | 0.034 |
| D8S1825 | a055zg1 | 14.9 | 8.1/8p23-pter | 89.0 | 67.1 | 0.040 | 0.10 |
| D12S99 | 217xa7 | 13.9 | 12.1/12p13-pter | 66.5 | 41.4 | 0.0077 | 0.083 |
| D12S95 | 207ve1 | 97.7 | 12.2/12p13-q24 | 67.4 | 41.6 | 0.0067 | 0.043 |
| D13S170 | 240wh2 | 65.4 | 13.1/13q31 | 92.9 | 70.4 | 0.039 | 0.015 |
| D13S1315 | a058xd5 | 105.2 | 13.2/13q32-qter | 110.4 | 65.4 | 0.00035 | 0.0037 |
| D14S285 | 319vf5 | 50.0 | 14.1/14q13-23 | 57.5 | 41.1 | 0.049 | 0.33 |
| D16S420 | 238xb2 | 43.2 | 16.1/16p12 | 70.2 | 51.8 | 0.047 | 0.039 |
| D16S401 | 025tg9 | 45.5 | 16.1 | 56.9 | 34.0 | 0.0080 | 0.028 |
| D16S516 | 350vd1 | 98.3 | 16.2/16q24 | 75.7 | 55.4 | 0.038 | 0.11 |
| D16S511 | 312xd1 | 108.4 | 16.2 | 108.6 | 85.6 | 0.049 | 0.11 |
| D18S57 | 147yg7 | 63.2 | 18.1/18q12 | 101.2 | 73.5 | 0.018 | 0.033 |
| D18S474 | 295xh1 | 71.3 | 18.1 | 84.5 | 63.0 | 0.038 | 0.012 |
| D18S68 | 248yb9 | 94.4 | 18.2/18q22-23 | 97.1 | 72.9 | 0.032 | 0.020 |
| D18S61 | 193yf8 | 102.8 | 18.2 | 108.6 | 69.3 | 0.0016 | 0.0098 |
| D18S469 | 116yg11 | 109.0 | 18.2 | 79.7 | 50.6 | 0.0055 | 0.020 |
| D20S864 | a343xc9 | 0.0 | 20.1/20pter | 63.7 | 44.2 | 0.030 | 0.11 |
| D21S270 | 031xc5 | 41.3 | 21.1/21q22-qter | 97.0 | 73.7 | 0.038 | 0.11 |
| D21S268 | 260ze9 | 44.3 | 21.1 | 96.4 | 71.0 | 0.025 | 0.13 |
| D22S264 | — | 0–9 | 22.1/22q11 | 74.6 | 51.4 | 0.019 | 0.0098 |
| DXS1068 | 238yo11 | 56.2 | X.1/Xp11-21 | 34.8 | 21.9 | 0.044 | 0.27 |
| DXS998 | 224zg11 | 183.8 | X.2/Xq27 | 35.3 | 17.7 | 0.0078 | 0.019 |
Position on the chromosome is provided in cM from the telomere of the short arm, based on the Généthon linkage map (20). Candidate regions are numbered consecutively for each chromosome. Clusters of markers adjacent in the scan are assigned to a single region. The number of alleles IBD in affected sib pairs reported for each marker and the associated P value are calculated by the program sibpalna (S for shared, NS for not shared). The P value calculated by the multipoint analysis program genehunter (pM) is provided. The raw data for the genome scan are available on Généthon’s web site.
*
Ref. 20.