Table 3.
Evidence for linkage to chromosome 18 region 18.2 and chromosome 3 region 3.1 (Table 2) in genome scan families
| Locus | Marker | cM | S | NS | IBD | P |
|---|---|---|---|---|---|---|
| Chromosome 18 region 18.2 | ||||||
| D18S64 | 212xg5a | 12 | 67.4 | 58.6 | 53% | 0.22 |
| D18S68 | 248yb9 | 5 | 97.1 | 72.9 | 57% | 0.03 |
| D18S465 | 260yh1 | 5 | 92.6 | 49.1 | 65% | 0.00013 |
| D18S61 | 193yf8 | 2 | 108.6 | 69.3 | 61% | 0.0016 |
| D18S1125 | b304yb9 | 1 | 84.3 | 64.4 | 57% | 0.051 |
| D18S485 | 330yd9 | 4 | 89.6 | 63.4 | 59% | 0.017 |
| D18S469 | 116Yg11 | 1 | 79.7 | 50.6 | 61% | 0.0055 |
| D18S486 | 333wd5 | 3 | 47.8 | 26 | 65% | 0.0057 |
| D18S1161 | a085y1 | 2 | 82.9 | 63.9 | 56% | 0.058 |
| D18S1009 | a037zc9 | 3 | 72.2 | 64.2 | 53% | 0.25 |
| D18S1115 | b01xf5 | 1 | 44.7 | 35.3 | 56% | 0.15 |
| D18S554 | 296wd5 | 1 | 84.2 | 68.8 | 55% | 0.11 |
| D18S462 | 079xb3 | — | 74.2 | 69.2 | 52% | 0.34 |
| Chromosome 3 region 3.1 | ||||||
| D3S1303 | 225yd6 | 1 | 89.7 | 71.5 | 56% | 0.076 |
| D3S3513 | 217xb4 | 1 | 88.5 | 83.7 | 51% | 0.356 |
| D3S3576 | a210ye9 | 1 | 78.6 | 61.9 | 56% | 0.079 |
| D3S1267 | 116xh2 | 0 | 86.1 | 63.4 | 58% | 0.032 |
| D3S3720 | a072ya5 | 3 | 96.8 | 73.1 | 57% | 0.035 |
| D3S1589 | 290zf1 | — | 80.7 | 64.4 | 56% | 0.089 |
Genetic distances to the next locus (in cM) are based on the Genethon linkage map (20). The number of alleles IBD in affected sib pairs and the associated P value are calculated by the program sibpalna (S for shared, NS for not shared).