Figure 6.2.

Strategy for the chemical genetics discovery approach. The reverse chemical genetics approach was used to discover dynasore. Dynasore is cell permeable and interferes with all functions known to be associated with dynamin. (From Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., and Kirchhausen, T. (2006). Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 10, 839–850; and Newton, A. J., Kirchhausen, T., Murthy, V.N. (2006). Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc. Natl. Acad. Sci. USA 103, 17955–17960.)