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. Author manuscript; available in PMC: 2010 Dec 9.
Published in final edited form as: J Am Chem Soc. 2009 Dec 9;131(48):17591–17596. doi: 10.1021/ja9049355

Figure 4.

Figure 4

(a) T2-weighted image of a moderate to late stage TRAMP mouse prostate tumor. Metabolite image overlays of the resonances corresponding to total hyperpolarized fructose (b) and composite β-fructofuranose-6-phosphate and β-fructofuranose (c) obtained after injection of 80mM [2-13C] fructose demonstrate spatial differences in total fructose versus the composite β-fructofuranose-6-phosphate resonance. Spectra corresponding to the two red voxels (d) in the tumor demonstrate the resonances corresponding to β-fructopyranose and the composite β-fructofuranose-6-phosphate and β-fructofuranose. Pyruvate and lactate resonances are shown from the same locations (e) obtained after an injection of 80mM hyperpolarized pyruvate in the same mouse.