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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Biochem Pharmacol. 2009 Sep 24;79(3):487–497. doi: 10.1016/j.bcp.2009.08.031

Figure 4. Mutation studies on the mouse Cox-2 promoter.

Figure 4

MMDD1 cells were transiently transfected with wild type of the pTIS10S reporter plasmid containing the murine Cox-2 promoter sequences, as well as the DRE mutant and C/EBP mutant. Cells were treated with 10 nM TCDD or with dioxane vehicle (control) for 24 h. Results are expressed as luciferase activity normalized to protein concentration and the statistically significant differences between control and TCDD treatment are indicated by * (p<0.05) or ** (p<0.01).