Table 1.

Pharmacokinetic variables and their definitions

Tmax	The time to the first occurrence of the maximum plasma concentration
Cmax	The observed maximum plasma concentration
AUC0-t	AUC to the last measurable plasma concentration (Cp), calculated by the linear trapezoidal rule
AUC0-inf	AUC calculated by linear trapezoidal rule to the last measurable Cp with additional area calculated from Cp/Kel. Kel is the elimination rate constant calculated from the slope of the terminal portion of the plasma profile calculated by least-squares regression of log (concentration) against time