Table 3.
Statistical analyses of partial AUC data
| Sodium ibuprofen (geometric means) |
Ibuprofen/ poloxamer (geometric means) |
Standard ibuprofen (geometric means) |
Ratio (%) sodium ibuprofen/ standard ibuprofen |
90% confidence interval | Ratio (%) ibuprofen/ poloxamer/ standard ibuprofen |
90% confidence interval | |
|---|---|---|---|---|---|---|---|
| AUC 0-0.08 (μg/h/mL) | Not estimated | Not estimated | Not estimated | Not estimated | Not estimated | Not estimated | Not estimated |
| AUC 0-0.17 (μg/h/mL) | 0.06 | 0.03 | 0.03 | 217.32 | 95.29-495.60 | 118.65 | 49.21-286.08 |
| AUC 0-0.25 (μg/h/mL) | 0.49 | 0.13 | 0.09 | 529.77 | 262.01-1071.16 | 138.56 | 68.53-280.17 |
| AUC 0-0.33 (μg/h/mL) | 1.61 | 0.50 | 0.18 | 905.93 | 462.33-1775.19 | 278.80 | 142.28-546.31 |
| AUC 0-0.42 (μg/h/mL) | 3.57 | 1.24 | 0.55 | 644.02 | 362.66-1143.69 | 224.33 | 126.32-398.37 |
| AUC 0-0.50 (μg/h/mL) | 6.09 | 2.34 | 1.31 | 466.40 | 287.78-755.90 | 179.01 | 110.45-290.13 |
| AUC 0-0.58 (μg/h/mL) | 8.99 | 3.72 | 2.30 | 390.44 | 251.21-606.85 | 161.71 | 104.04-251.34 |
| AUC 0-0.67 (μg/h/mL) | 12.08 | 5.39 | 3.52 | 343.55 | 227.18-519.53 | 153.34 | 101.40-231.89 |
| AUC 0-0.83 (μg/h/mL) | 18.03 | 9.24 | 6.36 | 283.49 | 195.09-411.95 | 145.21 | 99.93-211.00 |
| AUC 0-1.00 (μg/h/mL) | 23.71 | 13.65 | 9.54 | 248.48 | 176.57-349.68 | 143.08 | 101.67-201.35 |