Table 2.
Genotype frequencies at codon 72 of TP53 in colorectal cancer patients (n = 211)
| Arg | Arg/Pro | Pro | P value | |
|---|---|---|---|---|
| Cases, n (%) | 89 (42.2) | 94 (44.5) | 28 (13.3) | |
| Age (years +/- SD) | 64.7 +/- 10.8 | 64.8 +/- 11.2 | 63.2 +/- 10.2 | |
| Size (cm), n (%) | ||||
| <5 | 48 (42.5) | 52 (46.0) | 13 (11.5) | |
| ≥ 5 | 41 (41.8) | 42 (42.9) | 15 (15.3) | 0.707 |
| p53 mutations, n (%) | ||||
| wt | 22 (34.4) | 32 (50.0) | 10 (15.6) | |
| mt | 67 (45.6) | 62 (42.2) | 18 (12.2) | 0.313 |
| Mutations by codon 72 status, n | ||||
| Mutation on Arg | 67 | 26 | - | |
| Mutation on Pro | - | 36 | 18 | |
| Dukes' stage, n (%) | ||||
| A | 17 (40.5) | 21 (50.0) | 4 (9.5) | |
| B | 25 (41.7) | 27 (45.0) | 8 (13.3) | |
| C | 31 (41.3) | 30 (40.0) | 14 (18.7) | |
| D | 16 (47.1) | 16 (47.1) | 2 (5.9) | 0.622 |