Table 2.
The relationship between clinicopathological factors and plasma VEGF levels
| Plasma VEGF Levels, pg/mL | ||||
|---|---|---|---|---|
| Characteristics | No. (%) | Median | 25-75% Quartile | p Value |
| Age | ||||
| <60 | 79 (59) | 267.4 | 169.5 - 454.0 | 0.465 |
| >60 | 55 (41) | 262.7 | 146.6-385.4 | |
| Sex | ||||
| Male | 121 (90.3) | 264.0 | 154.0 - 392.6 | 0.151 |
| Female | 13 (9.7) | 338.4 | 262.0 - 459.4 | |
| Smoking | ||||
| Smokers | 108 (80.6) | 273.9 | 173.7 - 442.7 | 0.144 |
| Never-smokers | 26 (19.4) | 257.1 | 120.7 - 354.5 | |
| ECOG | ||||
| 1 | 39 (29.1) | 225.7 | 108.6 - 354.5 | 0.062 |
| 2-3 | 95 (70.9) | 282.0 | 182.3 - 446.0 | |
| Histology | ||||
| SCC | 103 (76.9) | 276.0 | 169.5 - 439.5 | 0.147 |
| ADC | 31 (23.1) | 262.0 | 132.3 - 338.4 | |
| Stage | ||||
| III | 87 (64.9) | 251.4 | 149.0 - 433.4 | 0.250 |
| IV | 47 (35.1) | 276.0 | 214.0 - 399.4 | |
| Tumor Size | ||||
| <3 cm | 44 (32.8) | 172.4 | 93.0 - 262.0 | 0.001 |
| >3 cm | 90 (67.2) | 339.9 | 218.0 - 484.5 | |
| T Factor | ||||
| T2-T3 | 66 (49.2) | 270.9 | 149.0 - 379.0 | 0.653 |
| T4 | 68 (50.8) | 263.0 | 157.6 - 439.7 | |
| N Factor | ||||
| N0-N1 | 65 (48.5) | 245.7 | 121.4 - 360.7 | 0.082 |
| N2-N3 | 69 (51.5) | 285.7 | 192.0-439.5 | |
| M Factor | ||||
| M0 | 87 (64.9) | 251.4 | 149.0 - 433.4 | 0.250 |
| M1 | 47 (35.1) | 276.0 | 214.0 - 399.4 | |
| Tobacco | ||||
| Yes | 25 (18.7) | 252.3 | 185.7 - 354.5 | 0.524 |
| No | 109 (81.3) | 267.4 | 154.0 - 433.4 | |
VEGF, vascular endothelial growth factor; ECOG, Eastern Cooperative Oncology Group; NSCLC, non-small cell lung cancer; SCC, squamous cell carcinoma; ADC, adenocarcinoma; T, tumor; N, node; M, metastasis