Table 2.
Summary odds ratios and p-values for the SNPs showing association with Lung Cancer
| rsID | Gene | Allelea | Chr | Positionb | Trend p-value | Unadjusted | Per Allele OR (95% CI) | Combined | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Stages 1&2 | Replication | Adjusted | Replication | Pchet | |||||||
| rs2808630 | CRP | C/T | 1 | 156493941 | 1.6 × 10−5 | 3.9 × 10−1 | 0.76 (0.67-0.86) |
0.88 (0.68-1.01) |
0.93 (0.79-1.10) |
1.00 | 0.93 (0.80-1.01) |
| rs7626795 | IL1RAP | A/G | 3 | 191833163 | 1.9 × 10−5 | 4.5 × 10−1 | 1.46 (1.23-1.74) |
1.17 (0.98-1.70) |
1.05 (0.93-1.19) |
1.00 | 1.05 (0.99-1.19) |
| rs2202507 | GYPA | A/C | 4 | 145615286 | 8.7 × 10−6 | 5.6 × 10−1 | 1.30 (1.16-1.46) |
1.20 (0.99-1.45) |
0.98 (0.91-1.06) |
0.18 | 1.01 (0.98-1.07) |
| rs11099666 | ARHGAP10 | A/G | 4 | 148991033 | 4.5 × 10−5 | 6.5 × 10−1 | 0.65 (0.53-0.80) |
0.94 (0.56-1.04) |
0.97 (0.85-1.11) |
0.87 | 0.96 (0.85-1.02) |
| rs1481847 | MSC | C/T | 8 | 72944049 | 1.2 × 10−5 | 7.2 × 10−1 | 1.30 (1.15-1.46) |
1.15 (0.99-1.45) |
1.01 (0.94-1.10) |
0.64 | 1.02 (0.99-1.10) |
| rs855974 | EMX2 | C/T | 10 | 119436858 | 1.4 × 10−5 | 9.1 × 10−1 | 0.74 (0.65-0.85) |
0.83 (0.65-1.01) |
1.00 (0.92-1.10) |
0.37 | 0.98 (0.91-1.02) |
| rs8034191 | LOC123688 | C/T | 15 | 76593078 | 1.9 × 10−5 | 2.2 × 10−14 | 1.30 (1.15-1.47) |
1.05 (0.99-1.44) |
1.33 (1.24-1.43) |
0.13 | 1.31 (1.22-1.40) |
| rs1051730 | CHR3 | C/T | 15 | 76681394 | 1.1 × 10−5 | 9.1 × 10−13 | 1.31 (1.16-1.48) |
1.16 (1.00-1.46) |
1.32 (1.22-1.43) |
0.28 | 1.30 (1.21-1.40) |
| rs12956651 | CBLN2 | A/G | 18 | 68265435 | 1.1 × 10−5 | 8.7 × 10−1 | 0.59 (0.47-0.75) |
0.71 (0.48-1.02) |
0.99 (0.85-1.14) |
0.41 | 0.96 (0.84-1.02) |
| rs6069045 | DOK5 | A/C | 20 | 52949270 | 8.6 × 10−6 | 7.5 × 10−1 | 0.75 (0.66-0.85) |
0.82 (0.67-1.01) |
1.01 (0.93-1.10) |
0.25 | 0.98 (0.92-1.02) |
a
Major/minor allele;
b
From NCBI build 139;
c
significance level (p-value) for testing equality of bias-adjusted and replication odds ratios