Table 3.
Summary odds ratios and p-values for the SNPs showing association with Colorectal Cancer
| rsID | Gene | Allelea | Chr | Positionb | Trend p-value | Unadjusted | Per Allele OR (95% CI) | Combined | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Stages 1&2 | Replication | Adjusted | Replication | Pchet | |||||||
| rs10411210 | RHPN2 | C/T | 19 | 38224140 | 2.0 × 10−7 | 6.9 × 10−4 | 0.79 (0.72-0.86) |
0.81 (0.72-0.95) |
0.90 (0.85-0.96) |
0.24 | 0.89 (0.84-0.94) |
| rs961253 | C/A | 20 | 6352281 | 7.8 × 10−7 | 3.4 × 10−5 | 1.13 (1.08-1.19) |
1.10 (1.00-1.18) |
1.11 (1.06-1.17) |
0.87 | 1.11 (1.06-1.15) |
|
| rs355527 | G/A | 20 | 6336068 | 7.8 × 10−7 | 3.4 × 10−5 | 1.13 (1.08-1.19) |
1.10 (1.00-1.18) |
1.11 (1.06-1.17) |
0.87 | 1.11 (1.06-1.15) |
|
| rs9929218 | CDH1 | G/A | 16 | 67378447 | 1.1 × 10−6 | 1.5 × 10−4 | 0.88 (0.84-0.93) |
0.91 (0.84-1.00) |
0.93 (0.90-0.97) |
0.71 | 0.93 (0.90-0.96) |
| rs4444235 | BMP4 | T/C | 14 | 53480669 | 5.6 × 10−6 | 1.8 × 10−4 | 1.12 (1.07-1.18) |
1.03 (0.99-1.17) |
1.10 (1.05-1.16) |
0.42 | 1.09 (1.04-1.14) |
| rs1862748 | CDH1 | C/T | 16 | 67390444 | 8.5 × 10−7 | 1.5 × 10−4 | 0.88 (0.84-0.93) |
0.91 (0.84-1.00) |
0.93 (0.90-0.97) |
0.64 | 0.93 (0.90-0.96) |
| rs4951291 | G/A | 1 | 202273161 | 6.6 × 10−6 | 5.7 × 10−1 | 0.85 (0.79-0.91) |
0.97 (0.80-1.01) |
1.02 (0.95-1.09) |
0.35 | 0.99 (0.95-1.01) |
|
| rs7259371 | RHPN2 | G/A | 19 | 38226481 | 3.4 × 10−6 | 2.1 × 10−3 | 0.86 (0.81-0.92) |
0.93 (0.81-1.01) |
0.91 (0.86-0.97) |
0.84 | 0.91 (0.86-0.97) |
| rs4951039 | A/G | 1 | 202273220 | 6.6 × 10−6 | 5.2 × 10−2 | 0.85 (0.79-0.91) |
0.97 (0.80-1.01) |
1.09 (1.00-1.19) |
0.03 | 0.99 (0.96-1.01) |
|
a
Major/minor allele;
b
From NCBI build 139;
c
significance level (p-value) for testing equality of bias-adjusted and replication odds ratios.