Table 7.
Summary odds ratios and p-values for the SNPs showing association with Type II Diabetes
| rsID | Gene | Allelea | Chr | Positionb | Trend p-value | Unadjusted | Per Allele OR (95% CI) | Combined | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Stages 1&2 | Replication | Adjusted | Replication | Pchet | |||||||
| rs864745 | JAZF1 | C/T | 7 | 27953796 | 4.9 × 10−9 | 1.3 × 10−7 | 1.10 (1.06-1.13) |
1.08 (1.03-1.12) |
1.10 (1.06-1.15) |
0.50 | 1.09 (1.06-1.12) |
| rs12779790 | CDC123 CAMK1D |
A/G | 10 | 12368016 | 1.4 × 10−8 | 1.5 × 10−4 | 1.12 (1.08-1.16) |
1.09 (1.04-1.15) |
1.09 (1.04-1.14) |
0.91 | 1.09 (1.05-1.13) |
| rs7961581 | TSPAN8 LGR5 |
T/C | 12 | 69949369 | 1.4 × 10−6 | 4.3 × 10−5 | 1.09 (1.05-1.13) |
1.05 (1.00-1.11) |
1.09 (1.04-1.13) |
0.31 | 1.08 (1.04-1.11) |
| rs758597 | THADA | C/T | 2 | 43644474 | 2.3 × 10−8 | 9.2 × 10−5 | 1.17 (1.11-1.24) |
1.13 (1.05-1.21) |
1.12 (1.05-1.20) |
0.80 | 1.13 (1.07-1.18) |
| rs4607103 | ADAMTS9 | T/C | 3 | 64686944 | 1.2 × 10−7 | 3.5 × 10−3 | 1.11 (1.07-1.15) |
1.08 (1.01-1.13) |
1.06 (1.01-1.11) |
0.65 | 1.07 (1.03-1.11) |
| rs10923931 | NOTCH2 | G/T | 1 | 120230001 | 4.3 × 10−7 | 1.9 × 10−3 | 1.14 (1.08-1.2) |
1.09 (1.00-1.17) |
1.11 (1.05-1.18) |
0.73 | 1.1 (1.05-1.15) |
| rs1153188 | DCD | T/A | 12 | 53385263 | 7.7 × 10−7 | 8.8 × 10−3 | 1.09 (1.06-1.13) |
1.06 (1.00-1.11) |
1.06 (1.02-1.10) |
0.91 | 1.06 (1.02-1.09) |
| rs17036101 | SYN2 PPARG |
A/G | 3 | 12252845 | 3.8 × 10−7 | 1.2 × 10−2 | 1.19 (1.11-1.27) |
1.12 (1.00-1.23) |
1.11 (1.02-1.2) |
0.88 | 1.11 (1.04-1.19) |
| rs2641348 | ADAM30 | A/G | 1 | 120149926 | 4.0 × 10−5 | 7.8 × 10−3 | 1.11 (1.06-1.17) |
1.01 (0.99-1.01) |
1.09 (1.03-1.16) |
0.12 | 1.07 (1.01-1.12) |
| rs9472138 | VEGFA | C/T | 6 | 43919740 | 1.1 × 10−5 | 9.5 × 10−2 | 1.09 (1.05-1.13) |
1.01 (0.99-1.1) |
1.03 (1.00-1.07) |
0.68 | 1.03 (1.00-1.06) |
| rs10490072 | BCL11A | C/T | 2 | 60581582 | 1.6 × 10−7 | 6.5 × 10−1 | 1.11 (1.07-1.15) |
1.08 (1.01-1.13) |
1 (0.97-1.04) |
0.06 | 1.01 (1.00-1.05) |
a
Major/minor allele;
b
From NCBI build 139;
c
significance level (p-value) for testing equality of bias-adjusted and replication odds ratios