Skip to main content
. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Genet Epidemiol. 2010 Jan;34(1):92–99. doi: 10.1002/gepi.20439

Figure 6. Association of SNCA REP1 with Parkinson's Disease.

Figure 6

Moving average frequency estimates for the three REP1 alleles (257 bp top panel, 259 bp middle, and 261 bp bottom) are plotted against age for controls (blue circles) and age at onset for patients (red triangles), each shown with 95% CPI (grey bar). The extreme low (ages ≤30 yrs.) and high (≥80) ages were collapsed. MAPs suggest inverse association with PD risk with 257 allele, no association with 259 allele, and increased risk of disease with 261 allele (for enlarged figure, see supplemental material). Moreover, the association with this locus appears to be mainly in the 35-50 year range.