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. Author manuscript; available in PMC: 2009 Dec 22.
Published in final edited form as: J Neurochem. 2009 Oct 3;111(6):1457–1465. doi: 10.1111/j.1471-4159.2009.06416.x

Figure 2. Facilitation of nNOS activity elicited via DA D1/5 receptor stimulation is dependent on NMDA receptor co-activation.

Figure 2

A) Representative recordings showing the effects of systemic administration of the D1/5 receptor agonist SKF (500 μg/kg, i.v.) delivered following intrastriatal infusion (120 min) of either aCSF, SCH (10 μM), or 7-NI (300 μM). Dotted line indicates time of SKF-81297 injection. B) Representative recordings showing the effects of systemic administration of the D1/5 receptor agonist SKF (500 μg/kg, i.v.) delivered following intrastriatal infusion of either KYN (100 nM), CPP (100 μM), or GLY (1 mM). Dotted line indicates time of SKF injection. C) The mean ± S.E.M. increase in NO efflux evoked by DA D1/5 receptor activation was significantly reduced following intrastriatal infusion of SCH, 7-NI, KYN, CPP (*p<0.05 as compared to SKF+aCSF group using ANOVA with Dunnett's post-hoc test, n=5–6 rats/group), but not GLY (p>0.05, n=4 rats).