TABLE 6.

PERFORMANCE OF TUBERCULOSIS SYMPTOM SCREENING IN DIFFERENT SOUTHERN AFRICAN SETTINGS

Author, Year	Location	N	HIV Prevalence (%)	Symptoms Included	Gold Standard	Sensitivity (%)	Specificity (%)
Communities
Corbett, 2008 (20)	Harare	8,979	21	Cough, weight loss, fever, hemoptysis, night sweats	Case definitions applied*	77	89
den Boon, 2006 (16)	Cape Town	1,170	<12†	Cough, hemoptysis, night sweats, fever, weight loss	Positive smear or culture at screening	69	68
Wood, 2007 (21)	Cape Town	762	23	Cough, night sweats, loss of appetite, loss of weight	2 positive smears or cultures at screening	33	74‡
Workplaces
Corbett, 2007 (17)	Harare factory workers	4,668	19	Cough, fever, hemoptysis, night sweats, unintentional weight loss	Case definitions applied*	59	—
Lewis§	South African gold miners	1,905	29	New or worsening cough (any duration), night sweats, weight loss	Case definitions applied*	31	90
HIV clinics
Mohammed, 2004 (19)	Cape Town HIV clinic, WHO stage III or IV	129	100	>1 of measured weight loss, cough, night sweats, or fever	Positive screening culture and symptoms or CXR	100	88.1
Day, 2006 (15)‖	South African gold miners	899	100	Cough, night sweats, weight loss	Case definitions applied*	59	76

Definition of abbreviations: CXR = chest radiographic abnormalities; WHO = World Health Organization.

^*Case definitions used screening and follow-up results from clinical examination, chest radiographic abnormalities, smear, and culture.

^†HIV testing was not done; HIV prevalence in this population was assumed to be less than the 12% reported from local antenatal clinics.

^‡Not able to calculate specificity as proportion with one or more symptom that did not have tuberculosis was not specified. Specificity for loss of weight reported as it had the highest specificity.

^§This study.

^‖Results did not differ by CD4 count.