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. 1998 Sep 1;95(18):10757–10762. doi: 10.1073/pnas.95.18.10757

Figure 1.

Figure 1

Similarity of PAGE-1, GAGE, and MAGE. (A) The predicted PAGE-1 reading frame is derived from the full-length PAGE-1 EST clone nh32c06. The GAGE and MAGE sequences are from SwissProt: GGE1, GGE2, GGE3, GGE4, GGE5, GGE6, MAG5, and MAG8_HUMAN. Note that the “MAGE alignment” matches amino acids that occur in MAGE5 and/or MAGE8, which are similar to PAGE-1 and/or GAGE1–6; the homologies between single members of the MAGE and PAGE and GAGE protein families are weaker. (B) Alignment of PAGE-1 with other PAGEs. PAGE-2 was translated from the EST ai61a04 EST cluster and PAGE-3 from om29f08. PAGE-3 was translated from one single EST and it is possible that the truncated N terminus results from a sequence artifact (the homology extends further to the N terminus in another reading frame). Several other so-far-undefined EST clusters were found that have homology to PAGE as well as to GAGE. These clusters do not have the striking similarities that the other GAGE family members have to each other, but they are also not significantly more similar to PAGE than to GAGE. Representatives of some of these cDNA clusters are the ESTs yd88e11 (fetal liver/spleen), yw86a06 (placenta), and yi21h01 (placenta).