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. Author manuscript; available in PMC: 2010 Apr 30.
Published in final edited form as: Cell. 2009 Oct 30;139(3):485–498. doi: 10.1016/j.cell.2009.09.033

Figure 1. Comparative analysis of the microbiota in the terminal ileum of C57BL/6 (B6) mice from Jackson Laboratory versus Taconic Farms.

Figure 1

A. Lumenal bacteria from both cecum and terminal ileum can induce Th17 cell differentiation upon transfer into Jackson B6 mice. Jackson B6 mice were gavaged with water (control) or with intestinal luminal contents from cecum or terminal ileum of Taconic B6 mice. LPL from small intestine were isolated 10 days later and analyzed for intracellular cytokines. Representative plots from one experiment with 3 mice per group. Plots gated on TCRβ+CD4+ LPL.

B. Phylogenetic tree based on 16S rRNA gene sequences of bacterial taxa detected in the terminal ileum showing significantly different relative abundances (PhyloChip fluorescence intensity) between the suppliers, Taconic and Jackson. Branches of the tree are color coded according to phylum while green and red bars display taxa with significantly greater relative abundance in Taconic and Jackson mice, respectively. The inner and outer dotted rings represents intensities corresponding to 5-fold and 25-fold differences in 16S copy number. The two taxa with the greatest difference between Taconic and Jackson mice, Lactobacillus murinus (~94-fold difference) and Candidatus Arthromitus (~40-fold difference), are noted by arrows.