Table 3. β₂^*-nAChR availability (V_T/f_P) throughout the Brain in Nonsmoker Controls and Smokers during Acute and Prolonged Abstinence.

	Nonsmoker	Smoker 1 day			Smoker 1 week			Smoker 2 weeks			Smoker 4 weeks			Smoker 6-12 weeks
Region	VT/fP*	VT/fP	% Diff**	P†	VT/fP	% Diff	P	VT/fP	% Diff	P	VT/fP	% Diff	P	VT/fP	% Diff	P
Thalamus	130.6±22.2	96.9±24.4	-26%	.002	138.5±25.9	+6%	.322	139.2±35.6	+7%	.461	133.8±19.3	+2%	.694	115.2±19.7	-12%	.140
Striatum	70.0±11.0	66.5±13.1	-5%	.492	85.1±16.8	+22%	.002	80.9±18.2	+16%	.070	79.5±12.6	+14%	.037	71.7±13.3	+2%	.760
Parietal Cortex	46.0±7.8	44.4±7.5	-3%	.659	56.6±9.9	+23%	.001	56.4±16.2	+23%	.144	52.3±10.9	+14%	.071	44.5±9.6	-3%	.714
Frontal Cortex	51.0±8.6	47.9±10.8	-6%	.450	61.8±13.0	+21%	.005	60.9±15.9	+19%	.158	58.3±13.8	+14%	.078	49.1±12.9	-4%	.685
Anterior Cingulate	52.5±7.8	54.8±7.7	+4%	.511	67.5±12.2	+29%	<.001	63.9±15.1	+22%	.098	61.4±10.0	+17%	.010	55.3±11.6	+5%	.500
Temporal Cortex	57.7±8.7	57.4±10.4	-1%	.941	70.2±12.8	+22%	.001	67.5±15.3	+17%	.048	66.1±9.7	+15%	.021	58.2±11.6	+1%	.908
Occipital Cortex	54.2±7.7	56.3±11.7	-4%	.587	68.6±13.4	+27%	.001	66.3±14.3	+22%	.067	64.1±10.3	+18%	.005	55.5±13.9	+2%	.771
Cerebellum	62.9±8.5	59.5±18.4	-5%	.649	77.9±15.5	+24%	.002	74.0±17.0	+18%	.143	73.2±11.5	+16%	.009	60.6±13.5	-4%	.605

^*V_T/f_P equals regional [¹²³I]5-IA uptake (kBq/cc)/free plasma parent (kBq/mL);

^**Percent Difference from Nonsmokers = ((Smoker-Nonsmoker)/Nonsmoker)*100;

^†p-values <0.00625 are significant after Bonferroni's correction