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. Author manuscript; available in PMC: 2009 Dec 22.
Published in final edited form as: J Biol Inorg Chem. 2008 Dec 13;14(3):421–438. doi: 10.1007/s00775-008-0459-3

Scheme 1.

Scheme 1

The synthesis of the hydoxylated DOTA-tetraamide ligands. Reagents and conditions i. (tBuOCO)2O / MeOH / tBuOH; ii. BnBr / KOH / DMF / RT; iii. CF3CO2H / CH2Cl2; iv. BrCH2COBr / K2CO3 / CH2Cl2 / 0 °C; v. cyclen / base / MeCN / 60 °C; vi. Pd(OH)2 on C / H2 / CH3CO2H / MeOH.