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. Author manuscript; available in PMC: 2009 Dec 22.
Published in final edited form as: J Biol Inorg Chem. 2008 Dec 13;14(3):421–438. doi: 10.1007/s00775-008-0459-3

Table 4.

Reaction conditions for the formation of 177Lu-labeled complexes and their partition coefficients and in vitro serum stability.

Complex Reaction conditions Radiochem. purity
(%)		 Rf logPc Serum stability at 24 h
(% intact)
177LuL1 n.c.a:
0.1 M NH4OAc
pH 6.5
2 h at 60 °C		 100 (n.c.a.) 0.41a 3.54 ± 0.42 100
177LuL2 100 (n.c.a.) 0.21b 5.23 ± 0.27 100
177LuL4 100 (n.c.a.) 0.74a 3.55 ± 0.27 100
177LuL8 c.a.:
1.2:1 ligand/lutetium
0.1 M NH4OAc
pH 6.5
2 h at 60 °C		 100 (n.c.a.) 0.79a 3.52 ± 0.43 100
177LuL12 100 (n.c.a.) 0.80a 3.98 ± 0.23 100
177LuL12 100 (c.a.) 0.82a n.d. n.d.

n.d.: not determined

c.a.: carrier added

n.c.a.: no carrier added

a

RP-18; 1:1 methanol/10% ammonium acetate

b

RP-18; 1:9 methanol/10% ammonium acetate

c

Determined in n-octanol/H2O.