Table 2.

Relationship Between Midlife Body Mass Index (BMI) and Changes in General Cognitive Ability, Controlling for Cohort, Education, Cardiovascular Diseases, Smoking, and Alcohol Use

Model Term	All		Excluding Persons With Dementia
	Estimate (SE)	p Value	Estimate (SE)	p Value
Age*	−0.288 (0.020)	<.0001	−0.285 (0.020)	<.0001
Age2†	−0.011 (0.001)	<.0001	−0.010 (0.001)	<.0001
BMI‡	−0.348 (0.112)	.002	−0.434 (0.118)	.0002
Age × BMI§	−0.015 (0.006)	.011	−0.015 (0.006)	.012

Notes: *Linear longitudinal change defined by age.

^†Curvilinear longitudinal change defined by age.

^‡Intercept, difference in mean BMI scores.

^§Slope, difference in trajectory of change due to age and BMI scores.