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. Author manuscript; available in PMC: 2009 Dec 22.
Published in final edited form as: Angew Chem Int Ed Engl. 2008;47(51):9814–9859. doi: 10.1002/anie.200801204

Scheme 2. Entry point into TDP-deoxysugar secondary metabolism in bacteria.

Scheme 2

Following thymidylylation of α-d-glucose-1-phosphate (17) by a thymidylyltransferase, a TDP-glucose-4,6-dehydratase enzyme catalyzes the conversion of TDP-d-glucose (20) to TDP-4-keto-6-deoxy-α-d-glucose (21) in the committed step to TDP-deoxysugar biosynthesis.