Table 2.
Baseline dopamine and metabolites
| DA | DOPAC | HVA | DA/DOPAC | DA/HVA | |
|---|---|---|---|---|---|
| Drug-naïve | |||||
| RYt8 | 8.93±2.3 | 331.0±99.2 | 4,210±1,024 | 0.027 | 0.0021 |
| RKn8 | 11.25±4.5 | 451.7±31.5 | 5,381±635.9 | 0.025 | 0.0021 |
| RDn8 | 14.00±4.0 | 232.4±51.5 | 4,209±1,367 | 0.060 | 0.0033 |
| Mean | 10.88±0.4 | 355.0±11.0 | 4,625±114.8 | 0.031 | 0.0024 |
| Limited access | |||||
| RYt8 | 7.44±2.6 | 221.4±42.2 | 3,610±651.8 | 0.034 | 0.0021 |
| RKn8 | 9.16±3.3 | 250.0±28.2 | 4,612±1,399 | 0.037 | 0.0020 |
| RDn8 | 4.93±3.1 | 175.1±33.0 | 2,712±583.7 | 0.028 | 0.0018 |
| Mean | 7.28±0.3 | 213.6±3.9a | 3,678±104.7a | 0.034 | 0.0020 |
| Extended access | |||||
| RYt8 | 8.39±4.4 | 194.8±128.7 | 3,156±282.1 | 0.043 | 0.0027 |
| RKn8 | 11.47±4.0 | 274.9±50.3 | 4,814±754.1 | 0.042 | 0.0024 |
| RDn8 | 2.53±1.0 | 105.1±61.6 | 3,083±761.9 | 0.024 | 0.0008 |
| Mean | 7.45±0.4 | 192.1±9.4a | 3,711±121.4a | 0.038 | 0.0020 |
Data represent nanomolar concentrations of dopamine and its metabolites, DOPAC and HVA, uncorrected for probe recovery, with SD for individual animals and SEM for the group mean
a
Significantly different from the drug-naïve state