Figure 2.

Electron microscopy study of oligomerization/fibrillization properties of Aβ variants. Transmission electron microscope analysis at each of the aggregation time points was performed, after negative staining with 1% uranyl acetate, using a Philips CM-12 microscope equipped with a Gatan (4k×4k) digital camera. Figure depicts the conformational assemblies of WT-Aβ40, E22Q, L34V, and Aβ42 after incubation under physiological salt concentration for 1, 3, and 6 d. Scale bars = 100 nm. Arrows indicate protofibrillar structures; arrowheads indicate fibrillar elements.