Figure 3. Synergistic dysregulation versus network size for candidate sub-networks associated with proteomic seeds obtained from Nibbe et al.

Sub-network dysregulation (i.e. mutual information of sub-network mRNA expression profile with phenotype class) versus network size for candidate sub-networks. All interactors (green squares) and crosstalkers (red diamonds) were scored using (a) GSE10950 and (b) GSE8671. The blue lines represent the linear interpolation of the means of the estimated null distributions computed for random candidate sub-networks of size 2,4,8,16,32, and 64, using the respective arrays (see Materials and Methods for details). Vertical bars represent one standard deviation from the mean.