Figure 4. Insulator proteins segregate differentially expressed promoters.

Log₂ enrichment or depletion of insulator binding sites between (A) adjacent promoters, (B) divergently transcribed promoters, (C) alternative promoters, and (D) cis-regulatory elements and promoters. (A–C) X and Y axes depict enrichment between differentially and non-differentially expressed promoters, respectively. (D) X and Y axes depict enrichment between CRMs and their nearest non-target promoter and their target promoter. Points and lines depict enrichment estimates and 95% confidence intervals.