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. 2009 Oct 8;284(49):33841–33849. doi: 10.1074/jbc.M109.048280

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Conformational scheme for the nAChR in reconstituted membranes. The effects of lipids on nAChR function have been interpreted previously using a conformational scheme involving resting (R), open (O), and desensitized (D) conformations (scheme 2). The nAChR in reconstituted membranes can be stabilized in an uncoupled conformation (14). Lipid effects on nAChR function in reconstituted membranes must therefore include equilibria between uncoupled (U) and coupled (R, O, and D) states (scheme 1).