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. 2009 Oct 7;284(49):33926–33938. doi: 10.1074/jbc.M109.023879

FIGURE 5.

FIGURE 5.

PARP-1 and PARG binding patterns are similar across individual target gene promoters. PARP-1 and PARG binding patterns are similar across individual promoters with both high and low occupancy. A, the occupancy of PARP-1 (black bars) and PARG (gray bars) at two regions (∼1 kb apart) of the GDF15, PVALB, LGALS3BP, and NELL2 promoters was determined by ChIP analyses. Each bar represents the mean + S.E. (error bars) from three or more independent determinations. Rel. Enrichment, relative enrichment. TSS, transcription start site. B, PARP-1 (solid line) and PARG (dotted line) occupancy was examined by ChIP-tiling analyses over a 2.5-kb region of the PVALB and LGALS3BP promoters. Each point represents the mean + S.E. (error bars) from three or more independent determinations; all values are statistically different from the no antibody control, as determined by a Student's t test with a p value threshold of <0.05.