TABLE 1.

General characteristics, plasma, and hepatic metabolite levels

Values are given as means ± S.E. for n = 6; *, p < 0.05 fenofibrate vs. control (Mann-Whitney U test).

Parameter	Control	Fenofibrate
Body weight change (%)	7.8 ± 1.0	−6.4 ± 2.0*
Food intake (g/day)	4.5 ± 0.1	4.8 ± 0.4
Plasma FGF-21 (ng/ml)	1.1 ± 0.1	4.7 ± 0.6*
Plasma NEFA (mmol/liter)	0.27 ± 0.04	0.20 ± 0.01
Plasma β-hydroxybutyrate (mmol/liter)	0.15 ± 0.03	1.00 ± 0.12*
Plasma triglycerides (mmol/liter)	0.53 ± 0.04	0.10 ± 0.01*
Liver weight (% body weight)	4.8 ± 0.1	13.2 ± 0.5*
Hepatic protein (mg/g)	160 ± 3	171 ± 2*
Hepatic C16 desaturation index	0.07 ± 0.01	0.13 ± 0.02*
Hepatic C18 desaturation index	1.20 ± 0.10	4.06 ± 0.20*
Hepatic triglycerides (μmol/g)	15.4 ± 2.6	24.6 ± 2.0*
Hepatic cholesterol (μmol/g)	7.7 ± 0.4	8.2 ± 0.3