TABLE 2.
Hepatic gene expression levels
Expression levels were normalized to 18S expression, and values are given as means ± S.E. for n = 6; *, p < 0.05 fenofibrate vs. control (Mann-Whitney U test).
| Gene | Control | Fenofibrate |
|---|---|---|
| Fatty acid mobilization/uptake | ||
| Fgf-21 | 1.0 ± 0.3 | 4.4 ± 0.4* |
| Cd36 | 1.0 ± 0.1 | 7.2 ± 0.7* |
| β-Oxidation and ketogenesis | ||
| Aox | 1.0 ± 0.1 | 4.5 ± 0.5* |
| Cpt-1a | 1.0 ± 0.1 | 1.4 ± 0.1* |
| Lcad | 1.0 ± 0.1 | 2.6 ± 0.2* |
| Hmgcs2 | 1.0 ± 0.1 | 1.9 ± 0.2* |
| Mitochondrial uncoupling | ||
| Ucp2 | 1.0 ± 0.1 | 2.9 ± 0.2* |
| Ucp3 | 1.0 ± 0.2 | 109.8 ± 9.6* |
| Fatty acid synthesis | ||
| Srebp-1c | 1.0 ± 0.1 | 1.3 ± 0.1 |
| Pgc-1ß | 1.0 ± 0.1 | 1.0 ± 0.1 |
| Acc1 | 1.0 ± 0.1 | 1.7 ± 0.1* |
| Fas | 1.0 ± 0.1 | 1.5 ± 0.1* |
| Elovl6 | 1.0 ± 0.2 | 1.3 ± 0.1 |
| Scd1 | 1.0 ± 0.1 | 2.6 ± 0.2* |
| Elovl5 | 1.0 ± 0.1 | 3.2 ± 0.3* |
| Fads1 | 1.0 ± 0.1 | 1.5 ± 0.1* |
| Fads2 | 1.0 ± 0.2 | 2.7 ± 0.3* |
| Triglyceride synthesis | ||
| Gpat | 1.0 ± 0.1 | 1.5 ± 0.1* |
| Dgat1 | 1.0 ± 0.1 | 2.0 ± 0.2* |
| Dgat2 | 1.0 ± 0.1 | 0.7 ± 0.1* |
| Glucose uptake/glycolysis | ||
| Chrebp | 1.0 ± 0.1 | 0.7 ± 0.1* |
| Glut2 | 1.0 ± 0.1 | 0.5 ± 0.1* |
| Gk | 1.0 ± 0.1 | 0.4 ± 0.0* |
| Pk | 1.0 ± 0.1 | 0.2 ± 0.0* |
| Pdk4 | 1.0 ± 0.3 | 27.0 ± 2.8* |
| Gluconeogenesis | ||
| Pgc-1α | 1.0 ± 0.1 | 1.1 ± 0.1 |
| Pepck | 1.0 ± 0.1 | 0.8 ± 0.1 |
| G6pc | 1.0 ± 0.3 | 0.8 ± 0.1 |
| G6pt | 1.0 ± 0.0 | 0.5 ± 0.2* |
| Gyk | 1.0 ± 0.1 | 1.8 ± 0.1* |
| PPP and NADPH synthesis | ||
| G6pdh | 1.0 ± 0.1 | 1.0 ± 0.1 |
| 6Pdgh | 1.0 ± 0.0 | 2.2 ± 0.1* |
| Taldo1 | 1.0 ± 0.1 | 1.8 ± 0.2* |
| Tkt | 1.0 ± 0.1 | 1.2 ± 0.1 |
| Me1 | 1.0 ± 0.1 | 5.9 ± 0.5* |