FIGURE 1.
Structure of antibody and CDR-derived peptidomimetics. A, schematic representation of the protein domain structure in antibodies (constant heavy chain (CH), constant light chain (CL), variable heavy chain (VH), and variable light chain (VL)), with amplified structural details for the variable fragment (Fv: CDR1, CDR2, and CDR3 of VH and VL chain). B, monocyclic, bicyclic, and tricyclic peptidomimetics are depicted together with molecular details for the scaffolds (T2 and T3) used in Chemical LInkage of Peptides onto Scaffolds methodology.